Essent Biologics works with pharmaceutical, medical device and research institutions to establish commercially-viable biomanufacturing processes that incorporate critical quality attributes into your cell-based product.

Our scientists and engineers leverage over 120 years of bioprocessing expertise to help you through the most challenging therapeutic hurdles. We also provide comprehensive data at every stage of tech transfer to empower you to commercialize your therapy sooner.

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case study

Validus Cellular Therapeutics is using an activated cell therapy to treat the most difficult infections – often these are drug-resistant or deep-seated infections that are hard for natural antibiotics to reach. With their cell therapy approach, Validus is seeking to infuse activated, allogeneic hMSCs to find and resolve that infection using the body’s innate immune mechanisms.

Essent Biologics is producing adipose-derived hMSCs for Validus, providing contract manufacturing services to train those cells to recognize infection and commercializing the therapy. Here’s a high–level overview of how it works:

  • Cells Migrate to Infection: Inactivated mesenchymal stromal cells have failed as therapeutics previously, due to the inability to locate to functional sites. Validus’ activated hMSCs migrate to the infection.
  • Recruitment of Immune Cells: Activated mesenchymal stromal cells recruit professional immune cells to the site of the infection to improve clearance.
  • Improve Infection Clean-Up: These immune cells, neutrophils, respond to infection and are more active at engulfing bacteria when they are stimulated by Validus’ activated mesenchymal stromal cells.
  • Rebuilding Correctly: Activated mesenchymal stromal cells recruit more “M2 polarity” macrophage (green) compared to “M1 polarity” macrophage (red). M2 macrophage are responsible for tissue repair and rebuilding whereas M1 macrophage result in breakdown and inflammation.

“Johnson, V., Webb, T., Norman, A. et al. Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections. Sci Rep 7, 9575 (2017)”

Validus Cellular Therapeutics

At Validus Cellular Therapeutics, we are innovating solutions to resistant infections using cellular therapies. We are always happy to consider new potential team members who believe they will provide valuable contributions to our our stated mission, vision and values.