Hofbauer Cells (Macrophages)
Hofbauer cells are the fetal-origin tissue macrophages, isolated from full term placenta after birth of a healthy child.
- Comprise CD68+ and CD163+ cells
- Competent for phagocytosis
- Thaw-and-use (cells are not expandable in culture)
PRICE:
$982.00 – $1,178.00
Hofbauer cells are highly specialized tissue macrophages which are found within the chorionic villi of the placenta throughout gestation. Fetal in origin, these cells perform the general functions associated with tissue macrophages including phagocytosis of apoptotic cells and presentation of antigens related to inflammation and infectious diseases.
The Amnion Foundation’s Hofbauer cells are isolated from full term placental tissue after careful microdissection of the chorion and enzymatic dissociation of the tissue. Cells are enriched based on surface protein expression and cryopreserved immediately after isolation without culture steps. Post-thaw morphology is typical of tissue macrophages and flow cytometric analyses confirm expression of CD68 and CD163 in each lot.
The role of Hofbauer cells in placental and fetal development is not fully understood but is an area of active investigation. Emerging evidence suggests roles for Hofbauer cells in promotion of vasculogenesis and formation of the villous tree as well as development of the placental mesenchyme. Hofbauer cells may also play a role in the vertical transmission of infectious agents, including Zika virus, from mother to child, making this cell type of particular interest in the study of infectious disease.
- Derived from human term placenta after a healthy birth and are fetal in origin
- 500K cells / vial post-thaw
- Product Code #
- AF1220 – Price: $982.00
- Vial Size: 2mL
- Single donor origin (non-pooled)
- Multiple Lots available from independent donors
- Uncultured; cryopreserved immediately after initial isolation
- Phenotypically characterized by flow cytometry (CD14, CD68, CD163, HLA-DR)
- Confirmed non-reactive for HBsAg, HBCore, HIV-1/HIV-2 + O, HTLV I/II, HIV/HCV/HBV NAT, West Nile Virus NAT
- Sterile; screened for endotoxin
- This non-GMP product is for research use only and cannot be used in therapy or diagnostics.
- Certificate of Analysis
- Instructions for Use
- Storage: < -150°C (Liquid Nitrogen)
- Shipped On: Dry Ice or Cryoport (customer preference)
Hofbauer Cells (Macrophages)
