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Human Native Tissue-Derived Type I Collagen

Scaffolds

As the main structural protein in the human body, native Type I Collagen is crucial to a vast array of medical and scientific research, providing structure to 3D scaffolds and an ideal ex-vivo environment for the attachment, proliferation, differentiation, and migration of cells.

Type I Collagen’s inherent self-organizing capacity, gel-forming characteristics, and abundant cell and matrix interaction domains make it ideal for two- and three-dimensional cell culture, labware coating applications, drug delivery, bioprinting, and as a scaffold for myriad tissue engineering modalities.

In molecular form, Type I Collagen has a triple helical conformation consisting of two genetically distinct alpha chains. The chains are generally composed of an amino acid sequence of Gly-X-Y where X and Y frequently are proline and hydroxyproline. The terminal domains of the collagen molecule are called telopeptides and these regions can be cleaved with proteolytic enzymes such as pepsin. When the telopeptides have been cleaved, the collagen is referred to as atelocollagen.

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New Product: Essent Launches Revolutionary Human Collagen

Selected Publications

George S, Abolbashari M, Kim TH, Zhang C, Allickson J, Jackson JD, Lee SJ, Ko IK, Atala A, Yoo JJ. Effect of Human Amniotic Fluid Stem Cells on Kidney Function in a Model of Chronic Kidney Disease. Tissue Eng Part A. 2019 Mar 2. doi: 10.1089/ten.TEA.2018.0371. [Epub ahead of print] PubMed PMID: 30829146.

Zani A, Cananzi M, Fascetti-Leon F, Lauriti G, Smith VV, Bollini S, Ghionzoli M, D’Arrigo A, Pozzobon M, Piccoli M, Hicks A, Wells J, Siow B, Sebire NJ, Bishop C, Leon A, Atala A, Lythgoe MF, Pierro A, Eaton S, De Coppi P. Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. Gut. 2014 Feb;63(2):300-9. doi: 10.1136/gutjnl-2012-303735. Epub 2013 Mar 24. PubMed PMID: 23525603.

Murphy SV, Atala A. Amniotic fluid and placental membranes: unexpected sources of highly multipotent cells. Semin Reprod Med. 2013 Jan;31(1):62-8. doi: 10.1055/s-0032-1331799. Epub 2013 Jan 17. Review. PubMed PMID: 23329638.

Skardal A, Mack D, Kapetanovic E, Atala A, Jackson JD, Yoo J, Soker S. Bioprinted amniotic fluid-derived stem cells accelerate healing of large skin wounds. Stem Cells Transl Med. 2012 Nov;1(11):792-802. doi: 10.5966/sctm.2012-0088. Epub 2012 Oct 29. PubMed PMID: 23197691; PubMed Central PMCID: PMC3659666.

Chun SY, Mack DL, Moorefield E, Oh SH, Kwon TG, Pettenati MJ, Yoo JJ, Coppi PD, Atala A, Soker S. Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters. J Tissue Eng Regen Med. 2015 May;9(5):540-9. doi: 0.1002/term.1631. Epub 2012 Nov 13. PubMed PMID: 23147868; PubMed Central PMCID: PMC3874429.

Cananzi M, Atala A, De Coppi P. Stem cells derived from amniotic fluid: new potentials in regenerative medicine. Reprod Biomed Online. 2009;18 Suppl 1:17-27. PubMed PMID: 19281660.

Hipp J, Atala A. Sources of stem cells for regenerative medicine. Stem Cell Rev. 2008 Spring;4(1):3-11. doi: 10.1007/s12015-008-9010-8. Review. PubMed PMID: 18286392.

De Coppi P, Bartsch G Jr, Siddiqui MM, Xu T, Santos CC, Perin L, Mostoslavsky G, Serre AC, Snyder EY, Yoo JJ, Furth ME, Soker S, Atala A. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol. 2007 Jan;25(1):100-6. Epub 2007 Jan 7. PubMed PMID: 17206138.

Delo DM, De Coppi P, Bartsch G Jr, Atala A. Amniotic fluid and placental stem cells. Methods Enzymol. 2006;419:426-38. Review. PubMed PMID: 17141065.

Essent Origin Sample™

Essent now offers flash-frozen origin tissue as companion products for each lot of cells. These well-preserved samples of adipose (adMSC), umbilical cord tissue (wjMSC), and skin uniquely connect donor tissue to isolated cells and enable vertical analyses with a high degree of context . Customers can take advantage of these paired samples in numerous ways, including genomic, transcriptomic, epigenomic, proteomic, and ultrastructural analyses. For additional information, please contact us.

punctuate your research

Just as punctuation gives clarity and structure to text, Essent Biologics’ products will create precision and results in your research. Consistent inputs and reliable supply of human biological materials, along with comprehensive donor and product data, means less variability for your research. Period.

know your source

Essent Biologics’ is partnering with AlloSource, an FDA compliant tissue bank (under 21 CFR Part 1271) with 25 years of experience, to provide you with quality tissues, cells and scaffolds for research. This collaborative relationship allows us to source novel biological materials and design them to suit your specific research needs. Having trouble sourcing a biomaterial? Contact us to see how we can help!

elevate your process

We know there are many paths to choose from when climbing the mountain that is research – from concept to market.  Essent’s highly-characterized* human mesenchymal stem cells (MSC) allow you to ascend that mountain faster and more easily.  Our reliable supply of biological materials produced under GMP compliant processes means the sky’s the limit when exploring research opportunities. Let us get you started or keep you moving.

*Cell characterization includes results for cell population doubling level, tri-lineage differentiation, flow cytometry markers, cell viability and morphology, growth characteristics and potency.

remove your limits

Our goal is to remove limitations and give you access to the tissues, cells, scaffolds and data essential to your research. We understand utilizing animal-derived cells and products may limit the relevance of and confidence in your research. Essent’s human-derived tissues, cells and scaffolds can provide additional confidence to advance to human clinical trials faster. We know your goal is to develop new medical solutions, and as a source for GMP-compliant biological materials, we prioritize accelerating your research through human clinical trials.

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